Morais S, et al. - Given that gastric first primary cancers (FPCs) have an increased risk of developing second primary cancers (SPCs), researchers assessed the contribution of SPCs to the mortality of gastric FPCs. For SPCs (December 31, 2012) and vital status (December 31, 2017), they followed a population-based cohort of gastric FPCs diagnosed in 2000-2006. Findings revealed that the 10-year cumulative mortality in males was 75.5% and in females with metachronous SPCs was 65.5%, which is more than 20% higher than for FPCs only. Among patients with gastric FPCs who survive long enough for metachronous SPCs, the latter significantly increases mortality over 10 years, while synchronous SPCs generally have a smaller effect.