Hulleman M, Oving I, Homma PCM, et al. - Given the association of out-of-hospital cardiac arrest (OHCA) at home with lower rates of shockable initial rhythm and survival than OHCA in a public location, researchers investigated if the association between OHCA location and presence of shockable initial rhythm and survival rate could be explained with medical history and medication use. From ARREST, an OHCA registry in the Netherlands, they assessed 1,404 patients: 1,034 [73.6%] home OHCA and 370 [26.4%] public OHCA. Analysis revealed no significant contribution of comorbidity and medication use in explaining the poor outcome from out-of-hospital cardiac arrest occurring at home. There remained a large gap of unexplained variance in shockable initial rhythm and survival even after adjusting for medical history, medication use, resuscitation characteristics, and demographics.