Wang Y, et al. - Via a retrospective review of all 280 subjects who presented with radiologically-identified renal mass with infiltrative features (2008-2017), experts investigated the full spectrum of such cases including those managed surgically or otherwise, with focus on clinical presentation/prognosis. The median age/tumor size was 65-years/6.9 cm, respectively, and 225 subjects were R.E.N.A.L. = 10-12. Overall, 181 subjects presented symptomatically, locally-advanced cancer and disseminated disease and/or lymphadenopathy were noted in 176 and 181, respectively. Clinical/radiographic conclusions were indicative of etiology and could direct assessment, however, for definitive diagnosis, they were nonspecific. The renal-mass biopsy was conducted in 103 subjects and diagnostic in 97. In 82 and 3 subjects, renal surgery and partial nephrectomy, respectively, was only done. Overall, 72 and 59 subjects received systemic chemotherapy and targeted therapy, respectively. Including 49 with highly-aggressive histology, final-diagnosis was renal cell carcinoma in 94 subjects. High-grade urothelial-carcinoma and lymphoma/metastatic cancer was discovered in 70 and 26/25, respectively. Overall, at a median of 5 months, 153 subjects died out of which 138 were cancer-related. At medians of 8, 3, and 2 months, respectively, the majority of subjects with renal cell carcinoma, urothelial carcinoma, and renal metastasis died, almost particularly cancer-related.