Karimzadeh A, et al. - Researchers performed a double-blind randomized controlled trial to determine the efficacy and safety of local injection of two corticosteroids (triamcinolone and methylprednisolone) at two different dosages, 20 and 40 mg in carpal tunnel syndrome (CTS) patients. They randomly assigned 80 patients with mild or moderate CTS to four groups: 20 or 40 mg triamcinolone (T20 or T40) and 20 or 40 mg methylprednisolone (M20 or M40) groups; each patient received a single injection of steroid using conventional approach. Outcomes support local injection of triamcinolone and methylprednisolone as efficacious and safe at doses of 20 and 40 mg. These injections were associated with a significant improvement in pain, functional status, and strength. No remarkable superiority was evident, however, 40 mg injection, especially for triamcinolone, yielded better nerve conduction study results and functional status