The Community-Level Interventions for Preeclampsia (CLIP) cluster randomized trials in Mozambique, Pakistan, and India: An individual participant-level meta-analysis
The Lancet Aug 26, 2020
von Dadelszen P, Bhutta ZA, Sharma S, et al. - Researchers attempted at reducing all-cause adverse outcomes with community-level interventions targeting women with pregnancy hypertension in three low-income countries in order to overcome the three delays in triage, transport and treatment that underlie adverse pregnancy outcomes. They conducted an individual participant-level meta-analysis via de-identifying and gathering data from the Community-Level Interventions for Preeclampsia (CLIP) cluster randomised controlled trials in Mozambique, Pakistan, and India, which were run in 2014–17. Recruitment was performed of consenting pregnant women, aged 12–49 years, in their homes. Clusters, defined by local administrative units, were randomly assigned (1:1) to either the control groups that continued local standard of care or the intervention groups that involved community engagement and existing community health worker-led mobile health-supported early detection, initial treatment, and hospital referral of women with hypertension. Overall, random assignment of 44 clusters (69,330 pregnant women) was performed; intervention groups comprised 22 clusters [36,008 pregnancies] and control groups comprised 22 clusters [33,322 pregnancies]. Outcomes revealed no reduction in adverse pregnancy outcomes in correlation with the CLIP intervention.
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