Chu L, Ren YL, Yang JS, et al. - Researchers sought to report on the sensitivity and specificity of the combinations of multiple factors associated with bone infection after artificial joint and to provide evidence-based medical basis for the early diagnosis of infection after artificial joint. They retrospectively reviewed 35 patients diagnosed with periprosthetic joint infections (PJI) or aseptic loosening (AL); both of these reported receipt of revision operation from January 2011 to January 2015. Observations revealed a high diagnostic value of CRP for PJI. A highly accurate diagnosis for PJI was made via histopathology HE staining, Gram staining, and 99mTc-MDP (technetium-99m labeled methylene diphosphonate). Hence, the findings support combining the unique clinical symptoms of PJI patients with relevant laboratory indexes, histopathologic characteristics, and imageological examinations to enhance diagnostic sensitivity and specificity of PJI in its early stage.