Wang C, Jin S, Xu S, et al. - By performing this retrospective study including 301 small cell lung cancer (SCLC) patients managed with platinum‐based chemotherapy, researchers determined the prognostic ability of pretreatment prognostic nutritional index (PNI), carcinoembryonic antigen (CEA), and neuron‐specific enolase (NSE) in SCLC. In univariate analysis, the identified predictors of overall survival (OS) included tumor stage, pretreatment PNI, CEA, NSE, distant metastasis numbers, and thoracic radiotherapy. The best OS (24.5 months) was experienced by patients with high PNI and NSE < 15 μg/L, while the worst survival outcome (10.0 months) was noted in patients with low PNI and NSE ≥ 15 μg/L. Pretreatment PNI and NSE were identified as the independent prognostic factors of SCLC. An enhanced OS predicting ability was conferred by the combination of PNI and NSE.