You Z, Li Y, Wang Q, et al. - Researchers conducted the study for analyzing the clinical significance of hepatic CD69 ⁺ CD103 ⁺ CD8 ⁺ resident memory T cells in autoimmune hepatitis. CD69 ⁺CD103 ⁺CD8 ⁺ TRM cells are reported to be significantly higher in the liver of patients with AIH vs chronic hepatitis B, non-alcoholic fatty liver disease and healthy control tissues. There was also a significant statistical association between elevation of CD8⁺ T_RM cells and severity of AIH disease. The data indicate that CD8⁺ T_RM cells play a critical role in AIH pathogenesis, and by direct inhibition of CD8⁺ T_RM cell expansion, glucocorticoids attenuate hepatic inflammation.