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The clinical expression and impact of multiple endocrine neoplasia 1 during pregnancy

Clinical Endocrinology May 21, 2020

Hogg P, et al. - Researchers conducted this retrospective case series to explore pregnancy outcomes in multiple endocrine neoplasia type 1 (MEN 1), characterised by multi‐system neoplasia including primary hyperparathyroidism and pituitary adenoma, positive women. The sample consisted of maternofoetal outcomes MEN 1 positive mothers managed at the Royal Hobart Hospital between 1967‐2018. Based on the Australian Institute of Health and Welfare data, information were retrieved from medical records and Australian averages calculated. Twenty‐six women with MEN 1 have been identified accounting for 96 pregnancies and 76 live born infants. Findings suggested an association of maternal MEN 1 with an increased risk of gestational diabetes, hypertensive disorders and low neonatal birthweight, but not with an increased miscarriage rate. While hypercalcaemia worsens during the second trimester, most pregnancies progressed without any overt complications or intervention requirements.

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