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The clinical characteristics and therapeutic outcomes of cryptococcal meningitis in elderly patients: A hospital-based study

BMC Geriatrics Mar 29, 2019

Tsai WC, et al. - In elderly patients in Taiwan, researchers analyzed clinical features and therapeutic results of cryptococcal meningitis (CM). The study was run for 15 years (2002–2016), during which 99 adult patients with CM were identified. Analysis was performed on 38 elderly (≥ 65 years) patients (16 men and 22 women, median age 72.9 years; range 65–86 years). Comparisons of clinical features and therapeutic results of these patients with that of non-elderly adult patients (< 65 years) with CM were carried out. According to the findings, compared with adults aged < 65 years, CM was observed more often in elderly patients (≥ 65 years). Female predominance, higher rates of changed consciousness, and recent cerebral infarction as the clinical presentation were observed in the elderly group vs non-elderly group. A significant prognostic factor in the elderly group was the presence of cryptococcemia.

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