Beard DJ, Davies LJ, Cook JA, et al. - A multicentre, pragmatic randomized controlled trial was conducted at 27 UK sites on 962 patients to evaluate the clinical efficiency and cost-effectiveness of total knee replacement (TKR) vs partial knee replacement (PKR) in patients with medial compartment osteoarthritis of the knee, and representing an analysis of the main endpoints at 5 years. Nearly 94% of individuals responded to the follow-up survey 5 years following their operation. At the 5-year follow-up, no variation in OKS between groups was observed. In our within-trial cost-effectiveness analysis, it was noted that PKR was more efficient and less expensive in comparison with TKR during the 5 years of follow-up. This conclusion was a result of slightly better outcomes, lower costs of surgery and lower follow-up healthcare costs with PKR vs TKR. In conclusion, both TKR and PKR are efficient, strive comparable clinical outcomes, and result in a relative incidence of re-operations and complications. On the basis of these clinical findings, and results about the lower costs and better cost-effectiveness with PKR during the 5-year study period, it was recommended that PKR should be acknowledged as the first choice for patients with late-stage isolated medial compartment osteoarthritis.