Kavolus JJ, Lazarides AL, Moore C, et al. - This study was undertaken to investigate if certain immunologic genotypes are predictive of the need for revision in patients with metal-on-metal (MOM) total hip implants. Researchers conducted a case-control study of all patients who had undergone primary MOM hip replacements (MOMHRs) between September 2002 and January 2012 with a minimum of 5-year follow-up. The investigational “case” cohort was comprised of patients who had undergone revision for MOMHR for a reason other than an infection. A potential genetic basis for failure was distinguished by conducting a single-nucleotide polymorphism array analysis. This analysis enrolled a total of 32 patients (15 cases and 17 control). This research distinguished an SNP, kgp9316441, encoding proteins associated with inflammation and macrophage activation. For MOMHR, this SNP was correlated with significantly increased odds of revision. Future trials are needed to validate this gene target both in vitro and in vivo.