Kavolus JJ, Lazarides AL. Moore C, et al. - This research was undertaken to ascertain if certain immunologic genotypes are predictive of the need for revision in patients with metal-on-metal (MoM) total hip implants. Researchers performed a case-control study including all patients undergoing primary MoM hip replacement between September 2002 and January 2012 with a minimum of 5 years follow-up. Researchers comprised the investigational “case” cohort of patients who had undergone revision for MoM hip replacement for a reason other than an infection. They conducted an SNP (single nucleotide polymorphism) array analysis to distinguish a potential genetic basis for failure. This analysis recruited a total of 32 patients (15 cases and 17 control). The findings distinguished a SNP, kgp9316441, encoding proteins correlated with inflammation and macrophage activation. This SNP was correlated with significantly elevated odds of revision for MoM hip replacement. Further research is needed to confirm this gene target both in vitro and in vivo.