Guida F, Tan VY, Corbin LJ, et al. - Findings indicate that blood metabolome has a potentially vital role in kidney cancer etiology.

• This study involved 1,305 kidney cancer cases and 1,305 healthy controls.

• Experts examined the link between kidney cancer and the levels of 1,416 metabolites measured in blood on average 8 years prior to the disease onset.

• A total of 25 metabolites were identified to be robustly linked with kidney cancer risk.

• Specifically, there was an inverse association of multiple glycerophospholipids with the risk, while several amino acids were positively related to risk.

• On accounting for body mass index (BMI), it was found that some—but not all—metabolites related to kidney cancer risk were impacted by BMI.