Fernández-Vega B, García M, Olivares L, et al. - In Northern Spanish individuals with age-related macular degeneration (AMD), researchers conducted this case-control study to illustrate the potential role of eleven single nucleotide polymorphisms (SNPs) in the most relevant lipid metabolism genes. The sample consisted of 228 unrelated native Northern Spanish patients diagnosed with AMD (73 dry and 155 wet) and 95 healthy controls. For each of the 11 sequence variants in the lipid metabolism genes, the allele and genotype frequencies did not exhibit significant differences in comparing AMD cases and controls. In the Northern Spanish population, a protective role for APOE-ε2 allele to wet AMD was suggested.