Wu YG, et al. - In Chinese osteosarcoma (OS) patients, researchers examined the association of X-ray repair cross-complementing group-1 (XRCC1) polymorphisms with risk, clinicopathologic features, and prognosis. They analyzed 146 patients with primary OS and 248 age- and gender-matched controls for the frequencies of four XRCC1 polymorphisms (rs25487, rs1799782, rs25489, and rs3213245). As per findings, XRCC1 rs3213245 polymorphism was correlated with increased risk of OS, which could influence XRCC1 expression in vitro and in vivo.