Mondal P, et al. - A retrospective chart review was performed to compare polysomnographic evidence nocturnal hypoxia (NH) with echocardiographic measures of pulmonary hypertension (PH) in children with sickle cell disease (C-SCD). Participants in the study were 20 C-SCD (Hemoglobin SS), who had polysomnography and echocardiogram performed within a narrow time interval, and 31% of them had pre-existing cardiac conditions. Results revealed that 25% of the subjects had NH and 40% of C-SCD, predominantly male, had evidence of PH based on an elevated tricuspid regurgitant jet velocity (TRJV). The findings from the present study suggested that NH was correlated with PH in C-SCD, and that screening for NH might help to identify C-SCD with higher morbidity risk.