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The association of late-life diabetes status and hyperglycemia with incident mild cognitive impairment and dementia: The ARIC Study

Diabetes Care May 28, 2019

Rawlings AM, et al. - Researchers examined how diabetes, glycemic control, diabetes duration, and biomarkers of hyperglycemia impact incident mild cognitive impairment (MCI) and incident dementia in older adults. A prospective analysis study of 5,099 participants from the Atherosclerosis Risk in Communities (ARIC) who attended the fifth (2011–2013) exam was carried out. Between HbA1c, and incident dementia researchers found a J-shaped association. Incident dementia was also correlated with glycated albumin and fructosamine. Incident MCI correlated with HbA1c and fructosamine. Over a median follow-up of 5 years, diabetes status, poor glycemic control, and longer diabetes duration were linked to worse cognitive outcomes.

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