Waller R, et al. - Researchers here examined the association of early-life stress (ELS), measured across multiple domains, with future pain sensitivity. They employed data from Gen1 and Gen2 of the Raine Study to appraise the association between a wide range of early life stressors, including antenatally, and pressure and cold pain sensitivity at young adulthood. According to the cold pain sensitivity, two groups of participants were formed. They performed analysis utilizing both a complete case and multiple imputation method, adjusting for contemporaneous 22-year correlates, with comparable results in each model. Findings revealed an association of more problematic behavior at age 2 years with less pressure pain sensitivity at 22 years, with no interaction between problematic behavior and pain experience at 22 years. The odds ratio for high cold pain sensitivity increased with poor family functioning among those reporting a moderate/high pain experience at 22 years, however, no increase was observed among those reporting no/low pain experience. The outcomes suggest early life as a critical period of development affecting future nociceptive processing.