Teymoori F, Farhadnejad H, Moslehi N, et al. - This investigation was conducted within the framework of the Tehran Lipid and Glucose Study to examine the correlation of dietary insulin index (II), insulin load (IL), glycemic index (GI), and glycemic load (GL) with the risk of developing diabetes among the Tehranian adults. The sample consisted of 1,149 individuals [mean age 44.8 ± 10.4 years], aged ≥ 30 years, who were followed-up for a mean of 8.04 years. Food frequency questionnaire has been used to calculate the dietary GI, GL, II, IL at the baseline. After adjusting for age, gender, smoking, physical activity, daily energy intake, and BMI, higher dietary scores of the II, IL, GI, and GL were found to be linked to the increased risk of diabetes incidence per each ones SD increment in the scores. The results indicate that a high GL, GI, II, and IL diet will increase the incidence of diabetes. Instead of the glycemic index and the insulin index, the glycemic and insulin load will strongly predict the risk of diabetes.