Junna L, et al. - Focusing on mortality, a comparison was performed between people unemployed from stable, downsized and closed workplaces vs a reference group unexposed to unemployment. Researchers analyzed nationally representative register data of inhabitants of Finland aged 25–63 in 1990–2009 (n = 275,738). Among men unemployed from stable workplaces, downsized workplaces, and closed workplaces, the hazard ratio for substance use-associated mortality was estimated to be 2.43, 1.85, and 2.16, respectively, relative to the control group. The corresponding values among women were 3.01, 2.39 and 1.47. A link was identified between unemployment from stable workplaces and death from psychiatric and self-harm related conditions. For those unemployed after closure, a reduction was noted in the mortality attributable to ischemic heart disease and other somatic diseases. The excess mortality among the unemployed was in part explained by selection mechanisms. However, a possible causal link of substance-use outcomes among men and women as well as of fatal accidents and violence among men, with unemployment, was suggested.