The association between serum adipocyte fatty acid–binding protein and 3-month disability outcome after aneurysmal subarachnoid hemorrhage
Journal of Neuroinflammation Feb 26, 2020
Luo YG, et al. - Among Chinese patients who encountered aneurysmal subarachnoid hemorrhage (aSAH), researchers evaluated the 3-month prognostic significance of serum levels of fatty acid–binding protein (FABP4; an adipokine that plays a crucial role in the development of cardiovascular and metabolic diseases) on hospital admission in this prospective observational study. Patients were recruited from a stroke treatment center in Zhengzhou, China, and included aSAH patients (n = 418; median age = 58 years) who were hospitalized within 24 h. FABP4 was identified as an independent predictor of poor outcome and death, with raised risks of 7% and 5%, respectively. The integration of FABP4 and the current risk factors led to an improved reclassification of mortality as well as the link of mortality with the net reclassification improvement statistic, while FABP4 addition allowed better reclassification of a poor outcome as well as its link with both the integrated discrimination improvement and net reclassification improvement statistics. Overall, findings revealed the link of high serum FABP4 levels with poor outcome and mortality in this patient population.
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