Ho LTS, et al. - In this study with 3010 cardiac surgical patients, researchers examined the link between cardiopulmonary bypass-associated platelet dysfunction and adverse outcomes [a composite of in-hospital death; myocardial infarction; stroke; deep vein thrombosis or pulmonary embolism; and acute kidney injury (greater than a two-fold increase in creatinine)] by using logistic regression and multivariable analyses. The occurrence of the outcome was reported in 251 (8%) of 3010 patients. Findings revealed an independent association of platelet dysfunction with the composite outcome, as observed after risk adjustment. An approximately 1% increase in the composite outcome was observed in relation to each 1% increase in platelet dysfunction. The prognostic value of cardiopulmonary bypass-associated platelet dysfunction was evident and it could have utility as a clinical measure of haemostatic activation in cardiac surgery.