Movsas TZ, Gewolb IH, Paneth N, et al. - Whether an excess of luteinizing hormone (LH) and human chorionic gonadotropin is related to proliferative retinopathy of prematurity (P-ROP), was determined in a cross-sectional analysis of infants (gestational age of <26 weeks) with and without P-ROP. Researchers used dried blood spots obtained at 1 week and 4 weeks of age from 45 preterm infants (27 no-ROP and 18 P-ROP). Using ICD-9 codes, they identified P-ROP cases. Through electrochemiluminescence assays on the Meso Scale Discovery platform, they ascertained hormones levels. In female but not male infants, a link of high LH with P-ROP was identified. This increases the likelihood that there exist gender-specific hormonal determinants of aberrant retinal angiogenesis.