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The association between gravidity, parity and the risk of developing rheumatoid arthritis: A systematic review and meta-analysis

Seminars in Arthritis and Rheumatism Mar 20, 2020

Chen WMY, et al. - Researchers examined if an association exist between gravidity and parity and the development of rheumatoid arthritis (RA). Further, they sought to establish if the time elapsed since pregnancy/childbirth, the number of pregnancies/childbirths, and serological status influence this association. Using the terms “rheumatoid arthritis.mp” or “arthritis, rheumatoid/” and “pregnancy.mp” or “pregnancy/” or “parity.mp” or “parity/” or “gravidity.mp” or “gravidity/” (observational study filter applied), Medline/EMBASE (from 1946 to 2018) were searched and 20 studies (from 626 articles) comprising 14 case-control (4799 cases; 11,941 controls) and 6 cohort studies (8575 cases; 2,368,439 individuals) were included. The analysis provide no evidence supporting the association of gravidity and parity with the risk of RA development.

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