The association between genetic polymorphisms of interleukin 23 receptor gene and the risk of rheumatoid arthritis: An updated meta-analysis
Clinical Immunology Nov 20, 2019
Du J, et al. - In order to verify if there exists a link between seven single nucleotide polymorphisms of interleukin-23 receptor (IL23R) gene and susceptibility to rheumatoid arthritis (RA), researchers performed this meta-analysis. They computed statistical data by using RevMan version 5.3. This analysis included 16 articles including 11,816 RA patients and 14,268 healthy controls. Findings revealed a significant link between the rs11209026 polymorphism and RA susceptibility in Caucasians. RA patients of Caucasians and Asians exhibited a significantly increased frequency of G allele of IL23R/rs10489629. Also, Caucasians showed a significant link between the rs1343151 polymorphism and RA susceptibility. Overall, findings corroborated that the IL23R gene might be treated as a susceptible factor for RA.
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