Tsai DC, Chen HC, Leu HB, et al. - Researchers performed a longitudinal case-control study examining the patients with clinically diagnosed insomnia using the Taiwan National Health Insurance Research Database for the risk of incident age-related macular degeneration (AMD). The insomnia cohort (n = 15,465) comprised newly diagnosed insomnia cases (aged ≥ 55 years) and the control cohort (n = 92,790) comprised individuals without insomnia, matched for age, gender and enrolment time. During a mean follow-up period of 5.1 ± 2.8 years, 2,094 (1.9%) developed AMD, including 214 (0.2%) developing neovascular AMD. Relative to patients without insomnia, insomnia patients showed a higher tendency for developing subsequent AMD and had a higher incidence of exudative AMD. These findings suggest the independent value of clinically diagnosed insomnia as an indicator of the increased risk of subsequent AMD development.