Ke H, Li J, Lu B, et al. - This research was undertaken to evaluate whether an elevated proton pump inhibitor (PPI) dose enhanced the effectiveness of Helicobacter pylori (H. pylori) eradication and ascertain the appropriate cutoff intragastric pH value that could predict H. pylori eradication with bismuth‐based quadruple therapy. Researchers included a sum of 207 H. pylori-infected, treatment-naive patients in this prospective, open‐label, randomized controlled trial. Individuals were assigned randomly into Eso40‐group (esomeprazole 40 mg bid) and Eso20‐group (esomeprazole 20 mg bid), and their CYP2C19 genotyping status was assessed. This study’s findings demonstrate that bismuth‐based quadruple therapy resulted in high H. pylori eradication rates either in PPI standard or double doses. An association was found between a double dose of esomeprazole and better intragastric acid suppression. For the prediction of the successful H. pylori eradication, a median 24‐h intragastric pH of 5.7 could be an appropriate cutoff value.