Zhang Q, Chen W, Yun C, et al. - In this study with male patients with hyperuricemia combined with hypogonadism, the application value of serum 25(OH)D3, uric acid, triglyceride (TG), and homeostasis model assessment of insulin resistance (HOMA-IR) was assessed. This analysis involved 198 male patients with primary hyperuricemia, categorized as normal gonadal function group (normal group, n = 117) and hypogonadal function group (hypogonadism group, n = 81), based on free testosterone (FT) level, International Index of Erectile Function, and androgen deficiency in the aging male questionnaires. Higher levels of fasting plasma glucose, fasting insulin, homeostasis model assessment of insulin resistance, triacylglycerol (TG), serum uric acid (SUA), alanine transaminase were detected in hypogonadism group vs those of normal group, while lower levels of TT, FT, estradiol, 25(OH)D3 were identified in hypogonadism group compared with those of normal group. Findings demonstrated a positive correlation of serum 25(OH)D3, SUA, HOMA-IR, and TG levels with male hyperuricemia patients with hypogonadism. These carry vital application value in the diagnosis of male hyperuricemia patients with hypogonadism.