Vecchiola A, et al. - In a non-primary aldosteronism (PA) population, researchers investigated the correlation between aldosterone (renin or the plasma aldosterone/renin ratio [ARR]) and metabolic disorders and inflammatory/vascular biomarkers. Measurements of plasma and urinary aldosterone and plasma renin activity (PRA) were obtained from 275 patients of both genders, including adolescents and adults. Using Adult Treatment Panel III, metabolic syndrome (MetS) was detected. Assessments were made for renal, vascular, inflammatory and mineralocorticoid activity biomarkers. Findings revealed the correlation of ARR with the variables of MetS, BMI, SBP, DBP, potassium excreted fraction, LDL, PAI-1, microalbuminuria, and leptin. Overall, cardiometabolic risk extends beyond the classic PA threshold screening. Compared to aldosterone or renin alone, ARR could serve as a more sensitive marker of obesity, MetS and endothelial damage in non-PA patients.