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The adjusted global antiphospholipid syndrome score (aGAPSS) and the risk of recurrent thrombosis: Results from the APS ACTION cohort

Seminars in Arthritis and Rheumatism May 09, 2019

Radin M, et al. - In this cross-sectional study, researchers examined levels of adjusted Global AntiphosPholipid Syndrome Score (aGAPSS) in patients with antiphospholipid syndrome (APS) and history of recurrent thrombosis vs patients without recurrent thrombosis. From the AntiPhospholipid Syndrome Alliance For Clinical Trials and InternatiOnal Networking (APS ACTION) Clinical Database and Repository (“Registry”), 379 APS patients who presented with arterial and/or venous thrombosis were included. Patients with recurrent thrombosis (arterial or venous) had significantly higher aGAPSS compared to those without recurrence (7.8±3.3 vs 6±3.9). They observed higher aGAPSS among patients with recurrent arterial, but not venous, thrombosis when analyzed based on the site of the recurrence. Findings support the possible utility of the aGAPSS in risk stratification of patients based on the likelihood of developing recurrent thrombosis in APS.
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