Huang AS, Rogers BP, Sheffield JM, et al. - Researchers aimed at characterizing thalamic structural abnormalities in psychosis and a neurodevelopmental cohort. In addition, they examined whether nuclear volumes were linked with cognitive function. Using a recently developed, validated method for segmenting thalamic nuclei and complementary voxel-based morphometry, they assessed a cross-sectional sample of 472 adults (293 with psychosis) and the Philadelphia Neurodevelopmental Cohort (PNC), consisting of 1,393 youths (398 with psychosis spectrum symptoms and 609 with other psychopathologies) for thalamic nuclei volumes. Per findings, smaller thalamic association nuclei represent a neurodevelopmental abnormality linked with psychosis, risk for psychosis in youths, and cognitive impairment. Recognition of specific thalamic nuclei abnormalities in psychosis may aid in early identification of psychosis risk and management of cognitive impairment in psychosis.