Bocchetta M, et al. - Using automated segmentation of T1-weighted MRIs to extract volumes of 14 thalamic nuclei, a cohort of 402 frontotemporal dementia (FTD) people was contrasted with 104 age-matched controls in order to examine in vivo atrophy of the thalamic nuclei across the FTD spectrum. Stratification was done by clinical diagnosis [behavioural variant FTD (n = 180), semantic variant primary progressive aphasia (n = 85), nonfluent variant PPA (n = 114), PPA not otherwise specified (n = 15), and related motor neurone disease (n = 8), genetic diagnosis, and pathological confirmation]. In distinguishing between FTD groups, compared with the whole thalamic volume, the use of individual thalamic nuclei volumes gave greater exactitude. Across all FTD groups, the only structure impacted is the mediodorsal nucleus. Moreover, among FTD forms, differential involvement of the thalamic nuclei is observed, with a novel pattern of atrophy in the pulvinar in C9orf72 expansion carriers.