Betrouni N, et al. – Researchers identified imaging markers of early cognitive symptoms, potentially before usual signs (eg, atrophy) manifest in a cohort of 102 patients with Parkinson disease and 17 age-matched cognitively healthy control participants who underwent extensive neuropsychological evaluation and T1-weighted MRI. Upon texture analysis, significant between-group differences for two features—skewness and entropy in the hippocampus, the thalamus, and the amygdala—were evident; however, volume analysis revealed no between-group difference. These features were significantly correlated with cognitive performance. Overall, the authors’ findings support the hypothesis that signal alterations linked to Parkinson disease=related cognitive decline may be caught early by texture analysis.