Cohen-Mekelburg S, et al. - A retrospective cohort study of one hundred forty-seven patients with inflammatory bowel disease (IBD) who were referred for small intestinal bacterial overgrowth (SIBO) breath testing from 1/2012 to 5/2016 was conducted to ascertain whether an improvement in IBD clinical activity scores is seen after testing and treating SIBO. Using Student’s t test for continuous variables and Chi-squared or Fisher’s exact test for categorical variables, characteristics of SIBO positive and treated patients were compared to SIBO negative patients, including the changes in Partial Mayo Score or Harvey Bradshaw Index (HBI). In an IBD population, this study examined the clinical effect of testing and treating for SIBO. A significant reduction in HBI was observed after testing for and treating SIBO.