Li Z, Chen S, Cui H, et al. - This study was carried out to distinguish the role of tenascin-C (TNC) in entheseal new bone formation and to explore the underlying molecular mechanism. Researchers obtained ligament tissue samples from patients with ankylosing spondylitis during surgery. They developed collagen antibody-induced arthritis and DBA/1 models to observe entheseal new bone formation. The results of this study demonstrate that inflammation-induced aberrant expression of TNC by fibroblast-specific protein-1+fibroblasts promotes entheseal new bone formation by suppressing extracellular matrix adhesion forces and activating Hippo signalling.