Koumarianou A, et al. - This is the first real-world data reporting from Greece on patient outcomes. Between 2006 and 2010, researchers statistically analyzed the clinicopathologic characteristics, treatments and outcomes of patients with potentially resectable gastric cancer (GC), the fifth most frequent cancer and the third cause of cancer-related deaths worldwide, managed at Attikon University General Hospital. In this observational study, the STROBE checklist was applied. The results of this retrospective cohort study indicated that gastrectomy with D1 or D2 lymphadenectomy significantly improves the survival of GC patients and is the optimal surgery for resectable GC patients. The worst negative prognostic factors for survival were microscopic and macroscopic infiltration of surgical margins. It is extremely important to achieve R0 (no cancer cells identified microscopically at the circular or linear, proximal or distal resection margin) surgical resection. These outcomes are equivalent to those of centers of excellence and show the urgent requirement for improvements in the field, especially in the development of predictive models for personalized treatment.