Temporal trends in statin prescriptions and residual cholesterol risk in patients with stable coronary artery disease undergoing percutaneous coronary intervention
The American Journal of Cardiology Apr 10, 2019
Guedeney P, et al. - In this single-center study of 2,653 patients who underwent elective percutaneous coronary intervention (PCI) between January 2010 and May 2016, researchers assessed how well patients adhered to guideline-recommended statin therapy (GRST) and the rate of residual cholesterol risk (RCR) at follow-up following elective PCI. High-intensity statin (HIS) therapy for patients ≤75 years old and moderate-intensity statin (MIS) or HIS therapy for patients > 75 years was the definition of GRST. The definition of RCR at follow-up was <50% reduction in low-density lipoprotein cholesterol (LDL-C) with HIS or <30% with MIS for statin-naïve patients and LDL-C >70mg/dL for nonstatin-naïve patients. Female gender, previous myocardial, smoking, and higher LDL-C level at baseline were risk factors of RCR at follow-up. In patients who underwent elective PCI, a significantly improved rate of GRST at discharge has been reported over time but no appreciable change has been reported for the prevalence of RCR at follow-up. Based on these findings, it could be justifiable to further implement guidelines as well as novel or more intensive pharmacotherapy.
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