Rospleszcz S, et al. - Researchers used data from 7,789 men and women aged 40–74 years from three prospective population-based cohort studies in Southern Germany in 1989-1990, 1994-1995 and 1999-2000, to investigate if there are temporal trends in the risk prediction performance of the Framingham Risk Score (FRS) and Pooled Cohort Equations (PCE) from 1990 to 2000, given the decreases seen in rates of cardiovascular disease (CVD) observed over the last 30 years. Using recalibrated equations of the FRS or PCE, they estimated 10-year CVD risk. They found that there were temporal trends in the performance of the FRS and PCE. Despite a satisfactory performance overall, further refinements of risk prediction models need to consider sex-specific trends.