Davis TME, et al. - This investigation draws on data from the longitudinal observational Fremantle Diabetes Study Phase II (FDS2) to assess the incidence of severe hypoglycaemia and its predictors in community-based patients with type 2 diabetes studied between 2008 and 2013 vs those in a cohort of patients with type 2 diabetes from the same geographical area evaluated a decade earlier. The study sample consisted of 1551 participants with type 2 diabetes. Older age, higher educational attainment, alcohol consumption, current smoking, sulphonylurea/insulin treatment, prior severe hypoglycaemia, renal impairment, and plasma N-terminal pro-B-type natriuretic peptide (NT-proBNP) were the independent predictors of incident severe hypoglycaemia in the FDS2. In the Fremantle Diabetes Study phases, the incidence and frequency of severe hypoglycaemia did not change, but novel risk factors, including plasma NT-proBNP, were observed in the FDS2.