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Temporal arteritis revealing antineutrophil cytoplasmic antibody–associated vasculitides: A case–control study

Arthritis & Rheumatology Jan 31, 2021

Delaval L, amson M, Schein F, et al. - This research was sought to present the clinical, biologic, and histologic presentations and outcomes in cases of temporal arteritis (TA) revealing antineutrophil cytoplasmic antibody (ANCA)–associated vasculitides (TA‐AAV) compared to controls with classic giant cell arteritis (GCA). Researchers compared the characteristics of patients with TA‐AAV to those of control subjects with classic GCA in this retrospective case-control study. The risk of treatment failure was evaluated by using a log-rank test, with hazard ratios and 95% confidence intervals (95% CIs). The study included a total of 50 patients with TA‐AAV (median age 70 years). As per the findings, TA‐AAV should be considered diagnostically in cases of atypical manifestations of GCA, refractoriness to glucocorticoid treatment, or early relapse. Analysis of temporal artery biopsy (TAB) specimens for the detection of small branch vasculitis and/or fibrinoid necrosis could be beneficial. The results of this study demonstrated that diagnosis of antineutrophil cytoplasmic antibodies should be performed in cases of suspected GCA with atypical clinical features and/or evidence of temporal artery abnormalities on TAB.

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