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Telomere length-associated genetic variants and the risk of thyroid cancer in survivors of childhood cancer: A report from the Childhood Cancer Survivor Study (CCSS)

Cancer Epidemiology, Biomarkers & Prevention Feb 01, 2019

Gramatges MM, et al. - Considering the previous findings describing an inverse relationship between telomere content and thyroid subsequent malignant neoplasm (thyroid SMN) in childhood cancer survivors, researchers investigated how known genetic determinants of leukocyte telomere length (LTL) relate to thyroid SMN in survivors. Using data from a large, genotyped survivor cohort, the Childhood Cancer Survivor Study, 118 survivors with thyroid SMN and 5,206 without thyroid SMN were identified. In survivors of childhood cancer, outcomes suggest no strong relation between variation in common SNPs influencing LTL and the risk of thyroid SMN.

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