Calvo DT, et al. - The main purpose of the present study was to investigate predictive variables of recovery after three years follow-up in patients with the first episode of psychosis (FEP). The study findings suggested that the degree of basal impairment in cognitive functions related to the Prefrontal Cortex and a worst premorbid adaptation anticipate in a significant way which patients were less likely to recover three years after an FEP.

Methods

• A longitudinal study was performed on three hundred ninety-nine patients with a first episode of psychosis (FEP).
• According to symptomatic and functional outcome, a dichotomic variable of recovery was created after 3 years follow-up.
• Finally, significant variables in univariate analysis were entered into a binary logistic regression to obtain a multivariate prediction model of recovery.

Results

• The study results showed that the predictive model was statistically significant and classified an overall of 76% of patients correctly, specifically 86.7% of patients that would not recover and 55% of the patients that would recover.
• Only speed of processing, executive functions and premorbid adjustment were found to be significant predictors of recovery from all the variables that where significantly different between recovered and not recovered patients.