Wong AK, et al. - Researchers sought to ascertain the efficacy of targeted epidural blood patches (EBP) under fluoroscopic guidance for persistent CSF leaks secondary to incidental durotomies. This case series is comprised of four patients with incidental durotomies after spine surgeries (one cervical decompression, one revision of L5-S1 decompression and fusion, and two lumbar decompressions). Under fluoroscopic guidance, they placed an 18-gauge epidural needle to convey EBP in all four patients. In some cases, the sites of CSF leak were further targeted via epidural catheters. Using contrast, the appropriate placements of the needles and catheters were confirmed. Via the needles or catheters about 5–14 mL of autologous blood was injected to the sites of the dural leak. Outcomes suggest a possible efficacy of targeted EBP in treating CSF leak from incidental durotomies. Following EBP, complete resolution of symptoms was reported in two out of three patients who had lumbar EBP. Symptoms did not improve in the patient who had cervical epidural patches indicating the higher difficulty in treating dural tears in the cervical region.