Shrotri M, van Schalkwyk MCI, Post N, et al. - In view of the significance of understanding the T cell response to SARS-CoV-2 for vaccine development, epidemiological surveillance and disease control strategies, researchers sought to critically examine and summarize the relevant peer-reviewed and preprint literature published from January 1,2020-June 26, 2020. Performing keyword-structured literature searches in MEDLINE, Embase and COVID-19 Primer, they identified 61 articles for inclusion. 55 (90%) studies used observational designs, 50 (82%) involved hospitalised patients with higher acuity illness, and the majority had important limitations. Findings suggest a complex pattern of T cell response to SARS-CoV-2 infection. However, because of significant methodological limitations and heterogeneity between studies, as well as a striking lack of research in asymptomatic or pauci-symptomatic individuals, inferences can not be made regarding population level immunity. Feasibility of population-level surveillance of the T cell response is unlikely in the near term; this is in contrast to antibody responses. Findings emphasize priortizing focused evaluation in specific sub-groups, including vaccine recipients.