Grand J, Miger K, Sajadieh A, et al. - Favorable short‐term and long‐term outcomes in acute heart failure (AHF) were reported in relation to increased systolic blood pressure (SBP).

• Four randomized controlled trials inquiring serelaxin vs placebo in patients admitted with AHF and SBPs from 125 to 180 mm Hg, were analyzed.

• This study included 10,533 patients with a mean age of 73 (±12) years and a mean SBP of 145 (±7) mm Hg.

• An inverse association of increasing SBP with both 180‐day mortality (adjusted hazard ratio [HR _adjusted ], 0.93 per 10 mm Hg increase) as well as with the composite endpoint (all‐cause mortality, worsening heart failure, or hospital readmission for heart failure the first 14 days) (HR _adjusted , 0.90 per 10 mm Hg increase) was observed.

• Predefined subgroup analysis revealed no link of baseline SBP with mortality in left ventricular ejection fraction (LVEF) ≥40%, but it was strongly related to mortality in patients with LVEF < 40%.