Jing X, Li C, Sun J, et al. - Researchers aimed at determining the most valuable marker of endometriosis-related infertility. Further, they examined predictive and diagnostic values of systemic inflammatory response markers (preoperative white blood–cell subtypes, neutrophil:lymphocyte ratio [NLR], platelet:lymphocyte ratio [PLR], and monocyte:lymphocyte ratio [MLR]) and CA125 levels in endometriosis patients. Assessment was performed of 662 women who had undergone laparoscopic surgery and been pathologically confirmed as having endometriosis and 83 patients pathologically confirmed with benign ovarian tumors. Lower NLR level was identified to be an independent risk factor of infertility. Patients with endometriosis showed significantly higher serum lymphocytes, while exhibited a rise in serum CA125, NLR, MLR, and PLR. Per observations, they suggest a possible utility of NLR as a simple and easily obtained predictive marker for endometriosis with infertility. Moreover, for diagnosing endometriosis, NLR can be a neoadjuvant biomarker for serum CA125.