Zhang X, et al. - This mediation analysis involved the exploration of systemic inflammatory mediators that mediate the impacts of obesity on asthma control. This work corroborated the role of systemic inflammation biomarkers, such as leptin, chemokine (C-C motif) ligand (CCL)17, interleukin (IL)-4, and IL-13, as mediators of the effects of obesity on asthma control.