Kalambokis GN, et al. - This research was to predict the occurrence of hepatorenal syndrome (HRS) and death in patients with advanced cirrhosis and ascites. The mean arterial pressure (MAP) and cardiac output (CO) were measured in all patients just before administration of 2 mg of terlipressin and 30 min later. It was deduced that higher Δsystemic vascular resistance (SVR), Model of End-stage Liver Disease score, and plasma renin activity (PRA) appeared to independently associated with the severity of cirrhosis. Data exhibited that SVR increased by at least 20% and a decrease in cardiac output (CO) at least 10% in response to terlipressin could predict HRS and mortality in patients with advanced cirrhosis.