Lv Z, et al. - To define the key prognosis influencing genes and relevant subtypes for lung adenocarcinoma (LUAD), researchers used the omics data of 515 LUAD samples from The Cancer Genome Atlas to identify significant mutations and prognosis-relevant genes. No direct impact of significant mutations on the prognosis was revealed. However, a collection of genes relevant to prognosis was identified, where experts further recognized the master genes that included 75 genes like GAPDH and GGA2 which are implicated in mTOR signaling, lysosome or other key pathways. The classification of LUAD patients into two sub-types was enabled by the master gene expressions, and these sub-types showed remarkable variations in expressional profiles, prognostic results and genomic mutations in specific genes, like SMARCA4 and COL11A1. By affording comprehensive information on the key prognosis-relevant genes and an alternative approach to group LUAD subtypes, this study can support the precision treatment of LUAD.